Thibault Sottiaux, Head of Codex at OpenAI, discusses the evolution of Codex from a niche developer tool into a general-purpose agent for knowledge work. He explores how this shift is redefining productivity, team dynamics, and our fundamental relationship with technology.
In this episode, Ben Lorica and Evangelos Simoudis discuss how AI is fundamentally reshaping the modern workplace. They explore the necessary evolution of knowledge work, from a focus on routine execution to problem definition and spec-driven development, and outline the critical skills professionals must cultivate—including rapid experimentation, AI agent orchestration, and systems thinking—to remain valuable and navigate a more volatile labor market.
Daniel Nadler, founder of OpenEvidence, discusses the platform's rapid adoption by 40% of US physicians. He explains how OpenEvidence solves the semantic search problem in high-stakes clinical decision-making, its growth strategy of treating doctors as consumers, and how AI will reshape medical education and the role of the physician.