Jul 28, 2026

OpenAI’s Plan to Make ChatGPT the Everything App — Akshay Nathan, OpenAI

Akshay Nathan, head of Core Product Engineering at OpenAI, discusses the journey and rationale behind ChatGPT Work. He explains how Codex's unexpected adoption by non-developers led to a unified agent harness, blurring the lines between developer and knowledge worker tools. The conversation delves into model capabilities, the role of artifacts and interactive 'Sites' in replacing traditional documents, and how AI fosters a new era of 'T-shaped' generalists. Nathan emphasizes the shift in productivity bottlenecks to 'ideas and taste' and the importance of 'quality at-bats' over mere 'motion' in an AI-powered development landscape.

May 14, 2026

Codex for Everyday Work: AI Agents Beyond Coding

Thibault Sottiaux, Head of Codex at OpenAI, discusses the evolution of Codex from a niche developer tool into a general-purpose agent for knowledge work. He explores how this shift is redefining productivity, team dynamics, and our fundamental relationship with technology.

Mar 07, 2026

AI Won't Replace You—But Someone Using AI Will

In this episode, Ben Lorica and Evangelos Simoudis discuss how AI is fundamentally reshaping the modern workplace. They explore the necessary evolution of knowledge work, from a focus on routine execution to problem definition and spec-driven development, and outline the critical skills professionals must cultivate—including rapid experimentation, AI agent orchestration, and systems thinking—to remain valuable and navigate a more volatile labor market.

Sep 04, 2025

No Priors Ep. 130 | With OpenEvidence Founder Daniel Nadler

Daniel Nadler, founder of OpenEvidence, discusses the platform's rapid adoption by 40% of US physicians. He explains how OpenEvidence solves the semantic search problem in high-stakes clinical decision-making, its growth strategy of treating doctors as consumers, and how AI will reshape medical education and the role of the physician.