Apr 02, 2026

Learning API Styles • Lukasz Dynowski & Sam Newman • GOTO 2026

This GOTO Book Club episode features an in-depth conversation between Sam Newman and Lukasz Dynowski, co-author of "Learning API Styles," exploring the foundational network layer of APIs, various API styles, critical trade-off decisions, and future trends like WebTransport and gRPC. The discussion emphasizes treating APIs as products, understanding consumer context, and the eight key characteristics of a well-designed API, complemented by a cautionary tale on database access.

Apr 01, 2026

Large-scale agentic quant research with Weights & Biases

Explore how Weights & Biases (W&B) enhances reliability, reproducibility, and explainability in large-scale, agent-driven quantitative research. This video demonstrates two core applications: debugging multi-agent alpha research pipelines with W&B Weave to identify root causes and iterate on forecasts, and automating strategy optimization using W&B Models to tune agent weights and gain insights from performance convergence and parallel coordinate plots.

Apr 01, 2026

"We're Not Writing Code by Hand Anymore. That's Over." | Owen Jennings & David Haber - The a16z Show

Owen Jennings, Executive Officer at Block, details the company's radical restructuring (40% workforce reduction) driven by AI's impact on productivity. He explains how Block is now operating with smaller squads, leveraging internal AI tools like Goose and Builder Bot, and shipping AI-native products like Money Bot and Manager Bot to deliver personalized, generative UIs for millions of users, emphasizing a future where unique understanding forms the ultimate business moat.

Apr 01, 2026

The Moonshot Podcast S2, Episode 2: Coding The Natural World

This episode of The Moonshot Podcast delves into the future of biological engineering, showcasing how AI and computational biology are transforming our interaction with living systems. Host Astro Teller first speaks with Brad Zamft of Heritable Agriculture about programming plants for increased yield, pest resistance, and drought resilience. Next, Relly Brandman from project A-Life explains how they're using AI to create a "virtual cell," shifting biomanufacturing from slow trial-and-error to a predictable engineering discipline for producing diverse materials like medicines, fuels, and textiles.

Mar 31, 2026

This AI Company Catches Fraud Across the Internet

Variance, emerging from three years in stealth with a $21 million Series A, is transforming enterprise risk and compliance through purpose-built AI agents. Founded by ex-Apple engineers, the company automates complex tasks like fraud detection, content review, and identity verification for Fortune 500s and platforms such as GoFundMe. They discuss the strategic reasons for stealth, technical challenges of integrating disparate data sources (including UI scraping), the shift from legacy systems to self-healing AI agent architectures, and how their lean, AI-maximalist team detects sophisticated threats like state-sponsored fraud rings.

Mar 31, 2026

LLM Compression Explained: Build Faster, Efficient AI Models

Learn how AI model compression and quantization techniques are essential for optimizing Large Language Model (LLM) performance and significantly reducing inference costs in production. This deep dive covers practical examples, benefits like reduced latency and increased throughput, and strategies for different AI use cases, demonstrating how to deploy scalable AI with minimal accuracy degradation.