Aug 04, 2026

Front End Testing with GitHub Actions • Amy Kapernick • YOW! 2025

This presentation by Amy Kapernick at YOW! Australia 2025 details how to implement robust front-end testing using GitHub Actions. It covers the rationale for comprehensive front-end testing, the necessity of a live deployment preview, and practical steps for automating tests like Lighthouse for performance/accessibility and Playwright for UI validation. The talk also delves into continuous deployment workflows and explores GitHub Actions' broader utility for workflow automation beyond testing, such as generating issues from code comments.

Aug 04, 2026

Chai Discovery's Bitter Lesson: Drug Design Is Another Scaling Problem

Chai Discovery is revolutionizing drug discovery by treating biology as an engineering problem, leveraging AI—particularly diffusion models and the "bitter lesson" of scaling—to design molecules rather than merely discover them. Their approach has boosted antibody design hit rates from 0.1% to 16%, aiming for a "Molecular CAD" suite that collapses discovery timelines from months to days. They partner with pharma, building infrastructure and creating a data flywheel to develop higher-quality, more targeted medicines for previously undruggable diseases.

Aug 04, 2026

What Are Large Database Models? AI for SQL Data

Martin Keen introduces Large Database Models (LDMs), a new AI paradigm that brings advanced analytical capabilities directly into SQL and relational databases. This allows for semantic queries on the 99% of enterprise data traditionally locked away, enabling faster, more secure insights without costly data movement.

Aug 04, 2026

The Constraint Your LLM Will Quietly Ignore (with Gurobi's Jerry Yurchisin)

Jerry Yurchisin from Gurobi Optimization explains mathematical optimization as an AI technology where constraints are hard guarantees, unlike LLMs which may ignore critical constraints. He outlines the three core building blocks of any optimization model: decision variables, constraints, and an objective function. The discussion highlights where optimization fits in the agentic AI era, with agents framing problems and generating code, then handing off to solvers like Gurobi via MCP servers. Jerry also covers advancements in non-linear solving, strategies for pitching optimization to stakeholders, and diverse case studies including energy grids, retirement planning, and USA Cycling's Paris 2024 gold medal.

Aug 03, 2026

Waymo Co-CEO Dmitri Dolgov: The Demo Is Only 1% Of The Work

Waymo co-CEO Dmitri Dolgov outlines seven crucial lessons from fifteen years of developing and scaling the Waymo Driver, the world's most advanced physical AI. He details the unique challenges of physical AI compared to digital, emphasizing the critical role of reliability, strategic technology choices, continuous innovation through foundation models, structure-augmented learning, high-fidelity simulation, AI flywheels, and robust evaluation frameworks to achieve superhuman safety and build trust in real-world autonomous systems.

Aug 03, 2026

Building Turbopuffer: Gergely Orosz (@pragmaticengineer ) × Simon Eskildsen (CEO)

Simon Eskildsen, CEO of Turbopuffer, discusses his unique path from early computer fascinations to founding an S3-native vector search company. He shares insights from his eight years at Shopify, detailing infrastructure scaling challenges and the development of Toxyproxy for fault injection. A core theme is his "napkin math" philosophy, using fundamental performance metrics to optimize systems and challenge benchmarks. He explains the impetus for Turbopuffer, its initial minimalist architecture, and how it achieved a 95% cost reduction for its first customer, Cursor. Simon also touches on the unexpected scarcity of CPUs due to AI workloads and his unconventional, principled approach to venture capital and building a remote-first company culture.