This conversation explores how AI's mathematical progress challenges traditional computing assumptions. It examines the shift from engineering-bound problems to capital-bound problems, impacting startups, incumbents, and venture capital, and considers the unpredictable potential of massively funded AI models.
Researchers from Boston Children's Hospital and OpenAI collaborated to apply AI (specifically, OpenAI o3 Deep Research) to tackle the "diagnostic odyssey" of rare diseases. By analyzing complex genomic and phenotypic data, the AI model helped identify 18 new diagnoses in 376 previously unsolved pediatric cases, showcasing its ability to accelerate literature review, generate hypotheses, and uncover obscure but critical information. This human-in-the-loop approach aims to make diagnosis faster, more accessible, and more precise, offering hope for personalized medicine and improved patient outcomes.