Nov 13, 2025

No Priors Ep. 140 | With Benchling Co-Founder and CEO Sajith Wickramasekara

Sajith Wickramasekara, CEO of Benchling, discusses the broken economics of drug development, where high costs and failure rates stifle innovation. He explains how the biotech industry is facing a 'dot com' bust and new competition from China, and argues that AI agents and simulation can provide the solution by making science less artisanal and helping scientists create better molecules through faster, cheaper experiments.

Nov 12, 2025

Sim: The Visual, End-to-End Agent Builder

Emir Karabeg, co-founder of Sim, shares the journey of building a visual, end-to-end platform for AI agents. He discusses their pivot from a failed idea, their explosive open-source growth strategy, the philosophy of building an AI-native workflow tool, and the operational culture that took them from a YC batch to 60,000 developers.

Nov 12, 2025

Satya Nadella – How Microsoft is preparing for AGI

Satya Nadella discusses Microsoft's massive AI infrastructure build-out, the transition to AI-driven business models, and the company's multi-pronged strategy for navigating competition, in-house model development, and the geopolitical landscape of AGI.

Nov 12, 2025

Magic Patterns: The AI Design Tool for Product Teams

Founders Alex and Teddy of Magic Patterns discuss their journey from numerous pivots to building a profitable, $1M ARR AI design tool with a two-person team. They share insights on finding product-market fit by focusing on customer obsession, the technical details of their prompt-to-prototype platform, and their experience in YC.

Nov 11, 2025

AI, AIOps & Agentic AI in Data Storage Observability

Prabira Acharya explains that managing data storage without observability is like driving a car without a dashboard. The talk outlines the seven pillars of storage observability, the critical role of AI in analyzing vast amounts of data for anomaly detection and predictive analytics, and the evolution toward agentic AIOps for creating self-healing and self-managing storage infrastructures.

Nov 11, 2025

Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users

Grant Lee, co-founder of Gamma, shares the journey of building a presentation tool to 100 million users and $100M ARR. He discusses the strategy of being 'different, not just better' than incumbents like Microsoft and Google, the importance of starting with a strong product thesis before integrating AI, and the disciplined 'hire painfully slowly' approach that allowed a small team to achieve massive organic growth.