Privacy-First Research with OpenSAFELY • Eli Holderness & Hannes Lowette

OpenSAFELY offers a new paradigm for medical research by bringing analysis code to sensitive patient data, rather than exporting the data itself. This interview explores its secure, privacy-preserving platform, its custom DSL `ehrql`, and how this model enforces reproducible, hypothesis-driven science while navigating the complexities of real-world clinical data.