An expert overview of post-training techniques for language models, covering the entire workflow from data generation and curation to advanced algorithms like Supervised Fine-Tuning (SFT), Direct Preference Optimization (DPO), and Reinforcement Learning (RL), along with practical advice on evaluation and iteration.
This talk introduces Anaximander, a system designed to bridge the gap between traditional, GUI-driven Geographic Information System (GIS) workflows and modern, code-heavy machine learning practices. Anaximander integrates geospatial foundation models directly into QGIS, allowing experts to interactively orchestrate, run, and evaluate models for tasks like semantic segmentation and object detection on satellite imagery.
At Applied Compute, efficient Reinforcement Learning is critical for delivering business value. This talk explores the transition from inefficient synchronous RL to a high-throughput asynchronous 'Pipeline RL' system. The core challenge is managing 'staleness'—a side effect of in-flight weight updates that can destabilize training. The speakers detail their first-principles systems model, based on the Roofline model, used to simulate and find the optimal allocation of GPU resources between sampling and training, balancing throughput with algorithmic stability and achieving significant speedups.
a16z co-founders Marc Andreessen and Ben Horowitz discuss the shift to a decentralized media ecosystem, their investment thesis on supply-driven markets, and the transformative impact of AI. They detail the a16z model of leveraging reputation as a core asset to turn inventors into CEOs and explain why AI represents a fundamental reinvention of computing that will unlock unprecedented growth.
Ben Luria, CEO of Hirundo, discusses the critical need for machine unlearning, framing it as a form of "AI neuro-surgery" for enterprise AI. He explains how this technique directly modifies model weights to remove unwanted data and behaviors, addressing core risks that superficial solutions like guardrails cannot solve.
State Space Models (SSMs) are emerging as a powerful and efficient alternative to Transformers for handling sequential data. Aaron Baughman explains the core concepts of SSMs, their mathematical foundations, and how architectures like S4 and Mamba address the memory and scalability challenges inherent in Transformers, leading to a new generation of faster, more intelligent hybrid AI models.
Nikesh Arora, CEO of Palo Alto Networks, shares his unconventional journey and leadership philosophy. He provides a masterclass in building a multi-platform company through strategic M&A, explains why founders should sometimes ignore customers, and reveals how to lead with conviction while managing imposter syndrome.
Stewart Butterfield, co-founder of Slack and Flickr, shares the product frameworks and leadership principles that guided his success. He delves into concepts like "utility curves" for feature investment, the "owner's delusion" in product design, and why focusing on "comprehension" is often more important than reducing friction. He also introduces powerful mental models for organizational effectiveness, such as combating "hyper-realistic work-like activities" and applying Parkinson's Law to team growth.
Intuit CEO Sasan Goodarzi discusses the operational playbook for reinventing a 40-year-old company, from its slow transition to SaaS to its early adoption of AI. He shares insights on winning the SMB market by treating small businesses like consumers, building effective channel partnerships, and developing a platform strategy. Goodarzi also details his leadership philosophy, emphasizing that grit and curiosity are more critical than raw talent.
OpenEvidence founder Daniel Nadler explains how his company solved the semantic search problem in medicine, achieving 40% adoption among US doctors in 18 months. He discusses the strategy of treating physicians as consumers, the future of medical education in the age of AI, and his unique philosophy on motivation and recruiting.
Paul Slaughter, creator of Conventional Comments, and Adrienne Braganza Tacke discuss how a structured, empathetic approach to feedback can transform code reviews from frustrating processes into productive collaborations. They explore the philosophy behind labeling comments, the importance of fostering collaborative ownership, and practical strategies for maintaining both politeness and efficiency in asynchronous, remote environments.
Experts discuss the Google antitrust verdict's impact on agentic AI, Anthropic's high valuation driven by its coding prowess, and whether the discourse around GPT-5 signals an "AI winter" or a necessary market reality check.
Professor Cristopher Moore of the Santa Fe Institute discusses the surprising effectiveness of AI, arguing it stems from the rich, non-random structure of the real world. He explores the limits of current models, the nature of intelligence as creative problem-solving and abstraction, the importance of grounding and shared reality, and the profound implications of computational irreducibility and the need for algorithmic transparency in high-stakes applications.
Alex Ewerlöf, author of "Reliability Engineering Mindset," discusses the significant gap between Google's idealized SRE practices and the resource-constrained reality of most companies. The conversation focuses on making Service Level Objectives (SLOs) practical by tying Service Level Indicators (SLIs) directly to business impact, using them as a data-driven communication tool to negotiate reliability costs, and moving from a "best practice" to a "fit practice" mindset.
Grant Miller explores the complex and evolving nature of AI agent identities within organizations, posing five critical questions about their classification, governance, and role alongside human employees.
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